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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Cell Calcium. 2023 Mar 31;112:102733. doi: 10.1016/j.ceca.2023.102733

Figure 2. The role of polycystin 1 and polycystin 2 in regulating signaling pathways that lead to cell death and or survival. A.

Figure 2.

PC-1 and PC-2 have been described to interact and/or regulate molecules within the Unfolded Protein Response (UPR) which is activated by ER stress. Red arrows indicates when upon activation of ER stress there is upregulation of PC-1 or PC-2. B. Diagram of the autophagic pathways implicated in PC-1/PC-2 pathways that are activated through cell stress, calcium-dependent pathways, or hypoxia. Red spheres indicate upregulation of the indicated molecules while blue-red gradient spheres indicate contradicting data upon deletion or mutation of PC-1 or PC-2. C. Model of the regulation of the polycystin proteins in autophagy. Dash arrows indicates uncharacterized mechanism. See text under Sections 4 and 5 for details. Molecules within each panel are labeled with the corresponding color.