Figure 6.
Confirmatory tests. We confirmed that the main findings were qualitatively preserved in two independent datasets: data collected at Kennedy Krieger Institute (KKI) and those recorded at Oregon Health and Science University (OHSU). The pure ASD and ASD+ADHD children had significantly infrequent transitions along the A–C/D–B pathway (A), which were correlated with their autistic socio-communicational symptoms (B). The frequency of the A–[C/D–E/F]–B transition was atypically higher in the pure ADHD children (C) and associated with their hyperactivity tendency (D). The intrinsic neural timescale of the left IPS in the pure ADHD children was atypically shorter than controls (E) and correlated with the atypically frequent A–[C/D–E/F]–B transition via the unstable activity of the DAN (F). The A–C–F–B transition frequency in the ASD+ADHD children was atypically frequent (G) and correlated with their cognitive instability (H). This atypical A–C–F–B transition frequency was correlated with the atypically shorter neural timescale of the left SFG (I) via the fluctuating neural activity of the FPCN (J). *pBonferroni < 0.05, †p < 0.05 for interaction in a two-way ANOVA. The error bars represent the SDs.