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. 2023 Jul 14;18(7):e0288598. doi: 10.1371/journal.pone.0288598

Table 1. Participant baseline characteristics.

  OBT+MVC OBT Total
  N Med/n IQR/% N Med/n IQR/% N Med/n IQR/%
Age, years 23 51 38 to 59 30 55 49 to 61 53 53 46 to 59
Male 23 20 87% 30 27 90% 53 47 89%
White 23 19 83% 30 28 93% 53 47 89%
BMI, Kg/m2 23 28 26 to 32 30 31 26 to 35 53 30 26 to 35
Waist circumference, cm 23 102 95 to 113 30 108 96 to 116 53 106 95 to 115
Systolic blood pressure, mmHg 23 129 124 to 136 30 132 121 to 141 53 130 123 to 140
Antihypertensive therapy 23 4 17% 30 7 23% 53 11 21%
Lipid lowering therapy 23 9 39% 30 14 47% 53 23 43%
Glucose lowering therapy 23 2 9% 30 4 13% 53 6 11%
Duration HIV infection, years 23 16 12 to 23 29 14 9 to 22 52 15 9.5 to 23
CCR5 tropic* 23 12  80% 30 20  83% 53 32  82%
CD4 count, cells/mm3 23 702 546 to 1007 30 745 514 to 1055 53 702 545 to 1035
HbA1c, mmol/mol 23 38 32 to 42 30 39 35 to 45 53 38 33 to 43
ALT, U/L 23 45 31 to 62 29 44 29 to 69 52 44 30 to 69
AST, U/L 23 32 24 to 39 28 33 22 to 58 51 32 24 to 44
GGT, U/L 23 45 32 to 112 30 41 26 to 58 53 42 30 to 72
Fasting LDL cholesterol, mmol/L 21 2.8 2.3 to 3.3 28 2.8 1.8 to 3.1 49 2.8 2 to 3.2
Fasting HDL cholesterol, mmol/L 22 1.2 1 to 1.4 30 1.1 0.9 to 1.2 52 1.1 0.9 to 1.3
Fasting Triglycerides, mmol/L 22 1.7 1.2 to 3.0 30 1.8 1.3 to 2.3 52 1.7 1.3 to 2.5
Fasting HDL: cholesterol ratio 22 3.9 3.5 to 4.7 30 4.3 3.5 to 4.8 52 4.0 3.5 to 4.8
Metabolic syndrome 23 11 48% 30 16 53% 53 27 51%
Fibroscan median LS, kPa 22 6.4 4.9 to 8 29 5.7 4.6 to 7.7 51 6.2 4.6 to 7.8
Fibroscan CAP score, dB/m 21 337 281 to 349 27 320 277 to 352 53 325 279 to 351
ELF score 22 9.2 8.5 to 9.5 29 9.0 8.7 to 9.6 51 9.1 8.6 to 9.6
NNRTI-based cART 23 8 35% 30 8 27% 53 16 30%
INSTI-based cART 23 11 48% 30 18 60% 53 29 55%
PI-based cART 23 4 17% 30 4 13% 53 8 15%
TAF 23 5 22% 30 10 33% 53 15 28%

*Tropism testing from HIV proviral DNA sequencing was successful for 39/53 (74%)

cART combination antiretroviral therapy, CAP controlled attenuation parameter, INSTI integrase strand transfer inhibitor, LS liver stiffness, MVC maraviroc, NNRTI Non-nucleoside reverse transcriptase inhibitor, OBT optimised background therapy, PI protease inhibitor, TAF tenofovir alafenamide