Table 4. Difference in change from baseline in quality of life outcomes for the maraviroc + OBT versus OBT group with bootstrapped 95% confidence intervals.
| Outcome | Week | N | Difference between MVC+OBT / OBT groups in change from baseline | 95% LCL | 95% UCL |
|---|---|---|---|---|---|
| CLDQ-NAFLD | 48 | 45 | -0.3 | -1.1 | 0.4 |
| 96 | 44 | -0.5 | -1.3 | 0.2 | |
| SF36 | |||||
| Physical function | 48 | 45 | -1.7 | -11.4 | 8.1 |
| 96 | 44 | -1.0 | -11.0 | 8.9 | |
| Role physical | 48 | 44 | 1.4 | -18.0 | 20.8 |
| 96 | 44 | 13 | -8.9 | 35.0 | |
| Role emotional | 48 | 44 | -0.6 | -27.3 | 26.2 |
| 96 | 44 | -14.5 | -36.0 | 6.9 | |
| Energy/fatigue | 48 | 43 | -0.2 | -10.4 | 10.0 |
| 96 | 43 | -1.8 | -11.9 | 8.3 | |
| Emotional wellbeing | 48 | 43 | 6.0 | -3.4 | 15.3 |
| 96 | 43 | 2.6 | -7.9 | 13.1 | |
| Social function | 48 | 44 | -4.1 | -16.0 | 8.0 |
| 96 | 44 | -4.9 | -19.2 | 9.4 | |
| Bodily pain | 48 | 43 | -1.3 | -15.6 | 12.9 |
| 96 | 43 | -7.5 | -19.7 | 4.7 | |
| General health | 48 | 45 | 2.9 | -7.1 | 12.9 |
| 96 | 44 | 1.5 | -7.2 | 10.3 | |
| WPAI:SHP | |||||
| % Work time missed | 48 | 25 | -10.5 | -25.6 | 4.7 |
| 96 | 25 | -8.2 | -22.8 | 6.3 | |
| % Impairment while working due to NAFLD | 48 | 29 | -2.6 | -21.3 | 16.1 |
| 96 | 30 | -7.1 | -21.0 | 6.7 | |
| % Overall work impairment due to NAFLD | 48 | 25 | -5.5 | -27.6 | 16.7 |
| 96 | 25 | -13.7 | -30.5 | 3.1 | |
| % Activity impairment due to NAFLD | 48 | 43 | 1.3 | -10.3 | 13.0 |
| 96 | 43 | 0.1 | -12.4 | 12.6 |
LCL, lower confidence interval, UCL upper confidence interval
CLDQ-NAFLD Chronic Liver Disease Questionnaire for NAFLD, SF36 36-item Short Form Survey, WPAI:SHP Work Productivity and Activity Impairment: Specific Health Problem