TABLE 2.
Outcomes of antegrade continence enema treatment at baseline and follow-up
| Baseline | 6 weeks | 6 months | 12 months | 24 months | 36 months | 48 months | 60 months | |
|---|---|---|---|---|---|---|---|---|
| Clinical outcomes | ||||||||
| ACE continued use | ||||||||
| Functional constipation, n/N (%) | n/a | 6/7 (86%) | 12/13 (92%) | 8/9 (89%) | 8/9 (89%) | 3/4 (75%) | 2/4 (50%) | 1/2 (50%) |
| Organic disorders, n/N (%) | n/a | 11/11 (100%) | 8/8 (100%) | 6/6 (100%) | 7/7 (100%) | 5/6 (83%) | 2/2 (100%) | 3/3 (100%) |
| ACE flush frequency | ||||||||
| Functional constipation, median (IQR) | n/a | 7 (7–7) | 7 (7–7) | 7 (7–8.5) | 7 (6–7.5) | 7 (5–7) | 7 (7–8) | 7 |
| Organic disorders, median (IQR) | n/a | 7 (7–7) | 7 (7–7) | 7 (7–7) | 7 (7–7) | 7 (7–7) | 3.5 (2–3.5) | 7 (3–7) |
| Fecal incontinence | ||||||||
| Functional constipation, n/N (%) | 14/22 (64%) | 1/7 (14%) | 2/13 (15%) | 1/9 (11%) | 1/9 (11%) | 1/4 (25%) | 1/4 (25%) | 2/3 (67%) |
| Organic disorders, n/N (%) | 9/16 (56%) | 3/11 (27%) | 3/8 (38%) | 3/6 (50%) | 3/7 (43%) | 2/5 (40%) | 1/3 (33%) | 2/3 (67%) |
| Hard stools | ||||||||
| Functional constipation, n/N (%) | 11/21 (52%) | 1/7 (14%) | 1/13 (8%) | 0/9 (0%) | 3/9 (33%) | 0/4 (0%) | 1/4 (25%) | 1/3 (33%) |
| Organic disorders, n/N (%) | 2/10 (20%) | 1/11 (9%) | 1/8 (13%) | 1/6 (17%) | 0/7 (0%) | 0/6 (0%) | 1/3 (33%) | 1/3 (33%) |
| Abdominal pain | ||||||||
| Functional constipation, n/N (%) | 16/22 (73%) | 5/7 (71%) | 6/13 (46%) | 3/9 (33%) | 4/9 (44%) | 2/4 (50%) | 2/4 (50%) | 3/3 (100%) |
| Organic disorders, n/N (%) | 4/11 (36%) | 2/11 (18%) | 2/8 (25%) | 3/6 (50%) | 3/7 (43%) | 1/6 (17%) | 2/3 (67%) | 2/4 (67%) |
| Patient satisfaction | ||||||||
| Parental satisfaction on scale from 0 to 10* | ||||||||
| Functional constipation, median (IQR) | n/a | 6.8 (3.2–9.7) | 8.7 (5.2–10) | 9.7 (6.5–10) | 9.0 (5.0–9.9) | 7.0 (0–7.0) | 5.0 (0–5.0) | 5.0 (0.5–5.0) |
| Organic disorders, median (IQR) | n/a | 9.8 (8.8–10) | 9.7 (9.0–10) | 8.7 (7.2–9.2) | 9.1 (8.6–9.9) | 8.8 (8.3–9.9) | 10 (7.4–10) | 9.1 (9.0–9.1) |
| Parental satisfaction: would probably or definitely choose ACE again† | ||||||||
| Functional constipation, n/N (%) | n/a | 3/5 (60%) | 9/10 (90%) | 9/9 (100%) | 10/11 (91%) | 3/3 (100%) | 2/3 (67%) | 2/3 (67%) |
| Organic disorders, n/N (%) | n/a | 12/12 (100%) | 8/8 (100%) | 7/7 (100%) | 8/8 (100%) | 6/6 (100%) | 3/3 (100%) | 3/3 (100%) |
| Child satisfaction on scale from 0 to 10* | ||||||||
| Functional constipation, median (IQR) | n/a | 6.9 (0.8–6.9) | 6.6 (4.4–9.2) | 7.6 (5.2–9.6) | 5.1 (3.7–10) | 9.3 (6.0–9.3) | 5.0 (0.0–5.0) | 2.7 (0.0–2.7) |
| Organic disorders, median (IQR) | n/a | 9.6 (7.1–10) | 9.7 (5.3–9.7) | 7.9 (5.0–7.9) | 9.2 (7.7–9.8) | 8.9 (5.7–9.9) | 9.5 (6.9–9.5) | 8.5 (7.3–8.5) |
| Child satisfaction: would probably or definitely choose ACE again‡ | ||||||||
| Functional constipation, n/N (%) | n/a | 1/3 (33%) | 4/5 (80%) | 4/8 (50%) | 4/7 (57%) | 2/3 (67%) | 1/3 (33%) | 0/3 (0%) |
| Organic disorders, n/N (%) | n/a | 4/5 (80%) | 2/3 (67%) | 3/3 (100%) | 4/4 (100%) | 4/4 (100%) | 2/3 (67%) | 2/2 (100%) |
ACE = antegrade continence enema; IQR = interquartile range.
*
On a Likert-scale from 0 to 10; higher scores represent higher levels of satisfaction.
†
On a scale from never, possible, maybe, probably, or definitely.
‡
On a scale from never, possible, maybe, probably, or definitely, only completed by children from 8 years of age.