TABLE 1.
Comparisons of Patient Characteristics in Training and Validation Cohort
| Characteristics | Training Cohort (n = 77) | Validation Cohort (n = 33) | ||||
|---|---|---|---|---|---|---|
| Low Ki67 Group (n = 27) | High Ki67 Group (n = 50) | P | Low Ki67 Group (n = 11) | High Ki67 Group (n = 22) | P | |
| Age, median (IQR), y | 66.0 (55.0–68.0) | 52.0 (44.0–61.0) | <0.001 | 60.0 (55.0–64.0) | 60.5 (47.0–68.0) | 0.720 |
| Sex, n (%) | 0.524 | 0.252 | ||||
| Female | 3 (11.1) | 9 (18.0) | 2 (18.2) | 1 (4.5) | ||
| Male | 24 (88.9) | 41 (82.0) | 9 (81.8) | 21 (95.5) | ||
| Liver cirrhosis (%) | 1 | 0.703 | ||||
| Absent | 9 (33.3) | 18 (36.0) | 3 (27.3) | 9 (40.9) | ||
| Present | 18 (66.7) | 32 (64.0) | 8 (72.7) | 13 (59.1) | ||
| Hepatitis B infection (%) | 0.048 | 0.643 | ||||
| Absent | 5 (18.5) | 2 (4.0) | 3 (27.3) | 9 (40.9) | ||
| Present | 22 (81.5) | 48 (96.0) | 8 (72.7) | 13 (59.1) | ||
| Serum AFP (%) | 0.004 | 0.109 | ||||
| ≤20 ng/mL | 16 (59.3) | 12 (24.0) | 8 (72.7) | 8 (36.4) | ||
| >20 ng/mL | 11 (40.7) | 38 (76.0) | 3 (27.3) | 14 (63.6) | ||
| Prothrombin time (%) | 0.248 | 1 | ||||
| ≤13 s | 21 (77.8) | 31 (62.0) | 8 (72.7) | 8 (36.4) | ||
| >13 s | 6 (22.2) | 19 (38.0) | 3 (27.3) | 14 (63.6) | ||
| PT INR (%) | 0.176 | 0.681 | ||||
| ≤1.0 | 10 (37.0) | 10 (20.0) | 2 (18.2) | 7 (31.8) | ||
| >1.0 | 17 (63.0) | 40 (80.0) | 9 (81.8) | 15 (68.2) | ||
| Total bilirubin (%) | 1 | 0.542 | ||||
| ≤20.5 μmol/L | 22 (81.5) | 41 (82.0) | 2 (18.2) | 7 (31.8) | ||
| >20.5 μmol/L | 5 (18.5) | 9 (18.0) | 9 (81.8) | 15 (68.2) | ||
| Albumin (%) | 0.631 | 0.389 | ||||
| ≤40 g/L | 12 (44.4) | 18 (36.0) | 2 (18.2) | 7 (31.8) | ||
| >40 g/L | 15 (55.6) | 32 (64.0) | 9 (81.8) | 15 (68.2) | ||
| Alanine aminotransferase (%) | 0.318 | 0.681 | ||||
| ≤50 U/L | 22 (81.5) | 34 (68.0) | 9 (81.8) | 15 (68.2) | ||
| >50 U/L | 5 (18.5) | 16 (32.0) | 2 (18.2) | 7 (31.8) | ||
| Aspartate aminotransferase (%) | 0.847 | 0.430 | ||||
| ≤40 U/L | 17 (63.0) | 34 (68.0) | 9 (81.8) | 14 (63.6) | ||
| >40 U/L | 10 (37.0) | 16 (32.0) | 2 (18.2) | 8 (36.4) | ||
| γ-Glutamyltransferase (%) | 0.711 | 0.456 | ||||
| ≤60 U/L | 16 (59.3) | 26 (52.0) | 8 (72.7) | 12 (54.5) | ||
| >60 U/L | 11 (40.7) | 24 (48.0) | 3 (27.3) | 10 (45.5) | ||
| Platelets (%) | 0.345 | 1 | ||||
| ≤125 ×109/L | 10 (37.0) | 12 (24.0) | 8 (72.7) | 12 (54.5) | ||
| >125 ×109/L | 17 (63.0) | 38 (76.0) | 3 (27.3) | 10 (45.5) | ||
PT INR indicates prothrombin time international normalized ratio.
P-values are statistically significant in boldface format.