Table 3.

Loss-of-function rare variants found in chronic pain samples from UK biobank 200k whole-exome sequencing cohort.

rsid	Pain	AF	N	BETA	SE	P	FDR	OR (95% CI)
rs28364172	Back	2.8E-03	96,058	0.41	0.10	2.7E-05	9.5E-05	1.5 (1.2-1.8)
rs138275989	Back	1.0E-03	96,058	0.18	0.16	2.6E-01	3.3E-01	1.2 (0.9-1.6)
rs201036744	Back	2.1E-05	96,058	0.98	1.10	3.8E-01	3.8E-01	2.7 (0.3-23.0)
rs769792098	Back	1.6E-05	96,058	−1.41	1.31	2.8E-01	3.3E-01	0.2 (0.02-3.2)
rs754331818	Back	1.8E-04	96,058	1.75	0.39	5.8E-06	4.1E-05	5.8 (2.7-12.4)
rs752434859	Back	2.1E-05	96,058	2.06	1.09	5.9E-02	1.0E-01	7.9 (0.9-66.4)
rs1563320610	Back	3.1E-05	96,058	1.85	0.85	2.9E-02	6.8E-02	6.4 (1.2-33.6)
rs28364172	Multisite	2.9E-03	137,168	0.13	0.03	8.6E-06	3.0E-05	1.1 (1.1-1.2)
rs138275989	Multisite	1.0E-03	137,168	0.04	0.05	0.4E-00	4.7E-01	1.0 (0.9-1.1)
rs201036744	Multisite	1.8E-05	137,168	−0.01	0.37	9.8E-01	9.8E-01	1.0 (0.5-2.0)
rs769792098	Multisite	1.1E-05	137,168	−0.74	0.48	1.2E-01	1.7E-01	0.5 (0.2-1.2)
rs754331818	Multisite	1.6E-04	137,168	0.58	0.12	2.5E-06	1.8E-05	1.8 (1.4-2.3)
rs752434859	Multisite	1.8E-05	137,168	1.02	0.37	5.6E-03	1.3E-02	2.8 (1.3-5.7)
rs1563320610	Multisite	2.2E-05	137,168	0.63	0.33	6.0E-02	1.1E-01	1.9 (0.9-3.6)

Columns show the rsid, pain site (Pain), allele frequency (AF) of the alternative allele, sample size (N), beta value from single variant analysis, and the corresponding standard error (SE), P values (P), FDR adjusted P values (FDR), and odds ratios (OR) with their 95% confidence intervals (95% CI).

FDR, false discovery rate.