Fig. 2. Elimination of Lrp1 in hepatocytes significantly delays time to death after RVFV infection.
(A) Lrp1f/f and Lrp1f/fAlb-Cre mice were infected with 20 plaque-forming units (PFUs) of RVFV ZH501 by footpad and monitored for survival (n = 61 animals, data were derived from three experiments). Clinical signs of (B) Lrp1f/f mice and (C) Lrp1f/fAlb-Cre mice highlight the frequency of neurological symptoms (note that mice found deceased are not included in this scoring). (D) Percentages of mice across three studies that experienced neurological signs of disease including tremors and paralysis (light blue) on the day of euthanasia in Lrp1f/f and Lrp1f/fAlb-Cre mice. Mice that were found deceased could not be clinically scored and were not included in analysis in (D). Kaplan-Meier survival analysis was completed to assess for significant differences between genotypes. ****P < 0.0001.