Skip to main content
. 2023 Jul 14;9(28):eadg7417. doi: 10.1126/sciadv.adg7417

Fig. 5. Single-nucleus RNA sequencing of LV samples from pediatric poLV patients confirms Kyn-AHR effect.

Fig. 5.

(A) Uniform manifold approximation and projection (UMAP) of the four LV samples in single-nucleus RNA sequencing. Cells were marked by cell types. (B) Cell proportion of different types in two groups. (C) AHR, ADAMTS2, COLA1, and FN1 expression of the LV samples between the two groups. (D) UMAP of the subcluster of CMs. (E) Cell proportion of CM subclusters between groups. (F) AHR and ADAMTS2 expression in total CMs between groups. (G) Cell proportion of CM types between groups. (H and I) AHR and ADAMTS2 expression in different CM types (H) and clusters (I) between groups. (J) UMAP of the subcluster of CFs. (K) Cell proportion of CF subclusters between groups. (L and M) AHR, FN1, and COL1A1 expression in total CFs (L) and subclusters (M) between groups. Significant differential expression was marked with “*” and under criteria of (i) lnFC > 0.25, (ii) P < 0.05, and (iii) min.pct > 0.1.