TABLE 2.

List of the top 5 significantly enriched Reactome and KEGG pathways and their corresponding proteins in AD versus Old platelets sorted after adjusted p-value.

Reactome Pathway	Proteins	FDR value
Innate Immune System	PYGB, PGRMC1, ARPC3, SKP1, RAC2, SNAP23, PSMB1, STOM, PSMB4, ARPC5, PA2G4, UBB, PSMD2, UBA7, RAC1, CYB5R3, RAB14, PSMB8, APRT, TXNDC5, PGM2, GRB2, ALAD, ARPC1B, PTPN6, NAPRT	4.72E-11
Immune System	PYGB, PGRMC1, ARPC3, SKP1, RAC2, SNAP23, PSMB1, STOM, PSMB4, STAT5B, EIF4A1, ARPC5, PA2G4, UBB, PSMD2, TCP1, UBE2O, UBA7, TUBA8, RAC1, CYB5R3, RAB14, PSMB8, APRT, TXNDC5, PGM2, GRB2, ALAD, ARPC1B, PTPN6, BCAP31, NAPRT	1.41E-09
Neutrophil degranulation	PYGB, PGRMC1, SNAP23, PSMB1, STOM, ARPC5, PA2G4, PSMD2, RAC1, CYB5R3, RAB14, APRT, TXNDC5, PGM2, ALAD, PTPN6, NAPRT	5.92E-09
Signaling by the B Cell Receptor (BCR)	SKP1, PSMB1, PSMB4, UBB, PSMD2, PSMB8, GRB2, PTPN6	1.24E-05
RHO GTPase Effectors	ARPC3, RAC2, ARPC5, YWHAG, ROCK2, TUBA8, RAC1, MYLK, GRB2, PAFAH1B1, ARPC1B	1.37E-05
KEGG Pathway
Parkinson disease	PPIF, PSMB1, PSMB4, UBB, PSMD2, UBA7, TUBA8, ATP5C1, VDAC2	2.30E-04
Prion disease	PPIF, RAC2, PSMB1, PSMB4, PSMD2, TUBA8, ATP5C1, VDAC2	2.30E-03
Proteasome	PSMB1, PSMB4, PSMD2, PSMB8	2.90E-03
Regulation of actin cytoskeleton	ARPC3, RAC2, ARPC5, ROCK2, MYLK, TMSB4X, ARPC1B	2.90E-03
Shigellosis	ARPC3, SKP1, SEPT11, ARPC5, UBB, ROCK2, ARPC1B	2.90E-03