TABLE 3.
List of the top 5 significantly enriched Reactome and KEGG pathways and their corresponding proteins in AD versus Young platelets sorted after adjusted p-value.
| Reactome Pathway | Proteins | FDR value |
|---|---|---|
| Platelet activation, signaling and aggregation | VCL, HRG, PLEK, F13A1, ENDOD1, PPBP, PF4, GP9, A2M, C6orf25, TMSB4X, CD9, MMRN1, GP1BB, GP5, TF, AHSG, ORM2, SERPINA1 | 4.74E-19 |
| Platelet degranulation | VCL, HRG, PLEK, F13A1, ENDOD1, PPBP, PF4, A2M, TMSB4X, CD9, MMRN1, TF, AHSG, ORM2, SERPINA1 | 1.42E-17 |
| Hemostasis | VCL, HRG, PLEK, F13A1, ENDOD1, PPBP, PF4, GP9, A2M, C6orf25, TMSB4X, CD9, MMRN1, GP1BB, GP5, TF, ITGA6, AHSG, ORM2, SERPINA1 | 2.27E-14 |
| Formation of Fibrin Clot (Clotting Cascade) | F13A1, PF4, GP9, A2M, GP1BB, GP5 | 8.42E-07 |
| Neutrophil degranulation | SLC2A3, VCL, COTL1, STOM, ARPC5, PPBP, S100A9, GSN, RAB14, AHSG, ORM2, SERPINA1 | 1.39E-06 |
| KEGG Pathway | ||
| Complement and coagulation cascades | C6, F13A1, A2M, C4BPA, SERPINA1 | 0.0011 |
| Hematopoietic cell lineage | GP9, CD9, GP1BB, GP5, ITGA6 | 0.0011 |
| Regulation of actin cytoskeleton | VCL, MYL9, ARPC5, GSN, TMSB4X, ITGA6 | 0.0024 |
| ECM-receptor interaction | GP9, GP1BB, GP5, ITGA6 | 0.0087 |
| Platelet activation | GP9, PTGS1, GP1BB, GP5 | 0.0233 |