TABLE 4.
List of the top 5 significantly enriched Reactome and KEGG pathways and their corresponding proteins in Old versus Young platelets sorted after adjusted p-value.
| Reactome Pathway | Proteins | FDR value |
|---|---|---|
| Platelet activation, signaling and aggregation | VCL, HRG, PLEK, F13A1, PPBP, PF4, GP9, A2M, TMSB4X, MMRN1, GP1BB, GP5, TF, AHSG, ORM2, SERPINA1 | 4.00E-16 |
| Platelet degranulation | VCL, HRG, PLEK, F13A1, PPBP, PF4, A2M, TMSB4X, MMRN1, TF, AHSG, ORM2, SERPINA1 | 1.65E-15 |
| Hemostasis | VCL, HRG, PLEK, F13A1, PPBP, PF4, GP9, A2M, TMSB4X, MMRN1, GP1BB, GP5, TF, ITGA6, AHSG, ORM2, SERPINA1 | 1.78E-12 |
| Formation of Fibrin Clot (Clotting Cascade) | F13A1, PF4, GP9, A2M, GP1BB, GP5 | 2.21E-07 |
| Intrinsic Pathway of Fibrin Clot Formation | GP9, A2M, GP1BB, GP5 | 1.10E-04 |
| KEGG Pathway | ||
| Complement and coagulation cascades | C6, F13A1, A2M, C8A, C4BPA, SERPINA1 | 1.06E-05 |
| ECM-receptor interaction | GP9, GP1BB, GP5, ITGA6 | 0.0074 |
| Hematopoietic cell lineage | GP9, GP1BB, GP5, ITGA6 | 0.0074 |
| Platelet activation | GP9, PTGS1, GP1BB, GP5 | 0.0127 |