TABLE 2.

Secondary Outcomes After Multilinear Regression Adjustment

Fluid Dose in cc/kg IBW	Overall	< 15 cc/kg IBW	15–25 cc/kg IBW	25.1–35 cc/kg IBW (aReference)	35.1–50 cc/kg IBW	> 50.1 cc/kg IBW
n	1,491	316	371	278	319	207
LOS
Expected LOS, d, median (IQR)	6.81 (5.30–11.03)	6.53 (5.18–10.92)	7.67 (5.59–12.71)	6.89 (5.39–10.51)	6.37 (5.18–10.00)	6.89 (5.30–10.83)
Observed LOS, d, median (IQR)	15.00 (7.00–34.50)	22.00 (8.00–34.50)	16.50 (6.00–34.50)	13.00 (6.00–34.50)	13.00 (6.00–34.50)	17.00 (7.00–34.50)
Observed/expected ratio, median (IQR)	1.67 (0.91–3.90)	1.99 (0.97–4.04)	1.66 (0.89–4.36)	1.56 (0.86–3.32)	1.52 (0.86–3.50)	1.73 (1.01–4.28)
% change from reference	—	–4.5	–5.9	1.43	–2.2	–1.6
p	—	0.302	0.194	0.044	0.660	0.833
Cost
Expected direct cost, dollars, median (IQR)	9,784.50 (6,738.25–17,447.25)	8,485.00 (6,125.50–16,877.00)	11,943.00 (7,584.75–21,318.25)	9,497.00 (6,622.25–15,544.25)	8,722.50 (6,401.00–15,181.50)	10,046.50 (7,130.50–17,957.00)
Observed direct cost, dollars, median (IQR)	19,061.50 (7,806.50–52,470.65)	34,265.00 (11,017.25–52,470.65)	20,033.00 (7,603.00–52,470.65)	14,703.50 (6,604.50–52,470.65)	14,234.00 (6,913.00–52,470.65)	23,680.00 (8,390.00–52,470.65)
Direct cost observed/expected ratio, median (IQR)	1.38 (0.78–3.66)	1.49 (0.86–3.80)	1.48 (0.79–4.25)	1.30 (0.74–2.85)	1.32 (0.70–3.19)	1.43 (0.79–3.75)
Change from reference, %	—	0.5	7.9	1.24	2.0	15.6
p	—	0.937	0.284	0.443	0.767	0.061
Mortality and hospice
Expired or hospiceb (%)	35.3	28.8	41.0	37.1	30.7	39.6
Odds ratio (95% CI)	—	1.026 (0.959–1.098)	1.064 (0.991–1.1441)	—	1.016 (0.95–1.088)	1.104 (1.023–1.192)
p	—	0.461	0.086	—	0.636	0.011

IBW = ideal body weight, IQR = interquartile range, LOS = length of stay.

^aThe group with fluid dose 25.1–35 cc/kg group was used as the reference group.

^bValues for expired/hospice LOS and direct cost were replaced with the 95th percentile highest value for the group.

Dashes indicate statistical significance of p = 0.05.