Table 1.

Clinical features of published cases of Hb Bristol-Alesha.

Reference	Nationality	Age at onset (month)	Sex	Hb (g/L)	Family history	Transfusion required	Splenectomy	Transplantation	Growth retardation	Specific features
Steadman et al., 1970 (11)	British	16	M	70	No	Yes	Yes	No	No	Hemolytic crisis, subarachnoid hemorrhages, and rheumatic fever
Ohba et al., 1985 (12)	Japanese	7	M	70-80	NR	1–1.5 units every 2 months	Yes	No	No	Gall stones
		NR	M	50-60	NR	4 units every month	No	No	Yes	Gall stones and hepatitis C
Aseeva et al., 1992 (13)	Russian	NR	M	70-80	NR	Yes	Yes	No	Yes	Thalassemic facies
Molchanova et al., 1993 (8)	Russian	2	M	80-90	No	6–8 times every year	Yes	No	Yes	Bone changes
Kano et al., 2004 (14)	Japanese	6	M	50-60	No	2 units every month	Yes	No	Yes	Hemolytic crisis and aplastic crisis
Brockmann et al., 2005 (15)	Germany	4	F	50-60	No	Once a month	Partial	No	NR	Central cyanosis, arterial hypertension, and Moyamoya syndrome
Eberle et al., 2007 (16)	Argentinean	6	F	84	No	Yes	Yes	No	Yes	Peculiar facial appearance
Jiang et al., 2016 (17)	Chinese	3	F	56	No	Yes	No	No	Yes	None
Pedroso et al., 2017 (18)	Brazilian	6	F	46	No	Once a month	No	Yes, but failed because of rejection	NR	Bone changes
Hamid et al., 2019 (19)	Iranian	NR	M	65	No	Yes	No	No	NR	None
Su et al., 2019 (20)	Chinese	4	M	61	No	Once every 2 weeks	No	No	No	None
Rizzuto et al., 2021 (21)	Spanish	4	M	70-80	No	8 units every year	Yes	No	Yes	None
Li et al., 2022 (22)	Chinese	3	F	60	No	Yes	No	Yes	Yes	None
Corrons et al., 2022 (23)	Indian	4	F	60	NR	Once a month	Yes	No	No	None

NR, not reported.