Table 1.
Baseline clinical characteristics of the training and validation sets.
| Characteristic | Total (n = 185) | Training set (n = 124) | Validation set (n = 61) | p value |
|---|---|---|---|---|
| Age (years) | 45 [42, 67] | 56 [50, 68] | 56 [45, 65] | 0.264 |
| Sex (male) | 168 (90.8%) | 110 (88.7%) | 58 (95.1%) | 0.511 |
| HBsAg | 0.081 | |||
| Negative | 30 (16.2%) | 17(13.7%) | 13 (21.3%) | |
| Positive | 155 (83.8%) | 107 (86.3%) | 48 (78.7%) | |
| ALT (U/L) | 31.00 [22.50, 51.00] | 36.00 [21.50, 57.35] | 32.50 [22.50, 54.00] | 0.677 |
| AST (U/L) | 40.50 [24.50, 45.55] | 40.00 [24.00, 46.50] | 42.50 [22.00, 55.75] | 0.846 |
| GGT (U/L) | 55.00 [38.50, 108.65] | 52.00 [35.50, 106.25] | 53.70 [32.45, 125.50] | 0.613 |
| ALP (U/L) | 82.50 [68.55, 102.50] | 81.00 [70.00, 106.00] | 85.00 [67.50, 108.55] | 0.327 |
| ALB (g/L) | 40.35 [35.30, 43.47] | 38.80 [37.58, 42.25] | 36.50 [35.50, 42.70] | 0.162 |
| TBIL (µmol/L) | 14.62 [12.00, 16.32] | 13.62 [10.34, 16.56] | 14.50 [12.60, 18.61] | 0.665 |
| SCr (U/L) | 75.20 [66.15, 87.50] | 75.60 [67.00, 86.85] | 76.00 [68.28, 87.30] | 0.548 |
| PT (s) | 11.60 [11.40, 12.50] | 11.80 [11.60, 12.60] | 11.95 [11.40, 12.58] | 0.756 |
| INR | 0.673 | |||
| ≤1.0 | 76 (41.1%) | 49 (39.5%) | 27 (44.3%) | |
| >1.0 | 109 (58.9%) | 75 (60.5%) | 34 (55.7%) | |
| NLR | 2.01 [1.44, 3.45] | 2.43 [1.83, 3.42] | 2.05 [1.58, 3.72] | 0.403 |
| PLR | 103.45 [70.55, 148.65] | 112.96 [83.15, 144.27] | 102.83 [71.30, 156.22] | 0.761 |
| AFP (ng/mL) | 24.35 [4.24, 132.41] | 18.55 [7.39, 92.32] | 28.53 [5.53, 545.00] | 0.206 |
Continuous variables are presented as median [inter-quartile range, IQR]. Categorial variables are presented as number (percentage). p-values represent the result of comparison of the training set with the test set.
HBsAg, hepatitis B surface antigen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, glutamyl transpeptidase; ALP, alkaline phosphatase; ALB, albumin; TBIL, total bilirubin; SCr, serum creatinine; PT, prothrombin time; INR, international normalized ratio; NLR, neutrophil to Lymphocyte ratio; PLR, platelet to Lymphocyte ratio; AFP, alpha fetoprotein.