Table 2.
Ontological analysis of the mutual DEGs between CRC and COVID-19.
| Category | Term | p-value | Genes |
|---|---|---|---|
| GO Biological Process | Neutrophil degranulation (GO:0043312) | 1.82E-09 | GSN/TNFAIP6/ANXA3/SLC11A1/HSPA6/MMP9/CEACAM1/PLAU/TCN1/CEACAM6/ANPEP/P2RX1/S100A12/CTSG/S100P/CD14/S100A9/S100A8/ELANE/CD177 |
| Neutrophil activation involved in immune response (GO:0002283) | 2.10E-09 | ||
| Neutrophil mediated immunity (GO:0002446) | 2.33E-09 | ||
| Regulation of inflammatory response (GO:0050727) | 1.17E-08 | MACIR/TNFAIP6/SERPINE1/OSM/MMP9/SBNO2/GPER1/PDCD4/S100A12/ENPP3/S100A9/S100A8/ELANE | |
| Cytokine-mediated signaling pathway (GO:0019221) | 2.55E-06 | IFITM3/IL1RN/IFITM1/CCL23/TNFRSF12A/MAOA/IL1R2/IFI6/OSM/MMP9/SOCS3/MT2A/CA1/CEACAM1/COL1A2/OAS3/PDCD4/CTSG | |
| Regulation of interferon-gamma production (GO:0032649) | 5.82E-06 | CD2/SLC11A1/SLAMF6/CD14/INHBA/VSIR/LGALS9C | |
| Negative regulation of viral entry into host cell (GO:0046597) | 8.66E-06 | IFITM3/IFITM1/GSN/LY6E | |
| Defense response to bacterium (GO:0042742) | 1.24E-05 | ANXA3/SLC11A1/OAS3/SERPINE1/S100A12/CTSG/S100A9/S100A8/ELANE | |
| Negative regulation of viral life cycle (GO:1903901) | 1.73E-05 | IFITM3/IFITM1/GSN/LY6E | |
| Regulation of cell migration (GO:0030334) | 2.56E-05 | ACVRL1/IFITM1/SERPINE1/SEMA3B/MMP9/VSIR/CXCL16/COL1A1/CEACAM1/PLAU/CEACAM6/GPER1/SGK1 | |
| GO Cellular Component | Collagen-containing extracellular matrix (GO:0062023) | 1.11E-08 | COL17A1/C1QB/C1QA/GDF15/SERPINE1/SEMA3B/CLU/MMP9/LOXL1/COL1A1/COL1A2/MMRN1/COL7A1/CTSG/S100A9/S100A8/ELANE |
| Secretory granule lumen (GO:0034774) | 9.41E-06 | GSN/MMRN1/TCN1/SERPINE1/HSPA6/S100A12/CTSG/S100P/CLU/S100A9/S100A8/ELANE | |
| Specific granule (GO:0042581) | 3.08E-04 | CEACAM1/PLAU/TCN1/ANXA3/P2RX1/ELANE/CD177 | |
| Cytoplasmic vesicle lumen (GO:0060205) | 3.27E-04 | GSN/HSPA6/S100A12/S100P/S100A9/S100A8 | |
| Tertiary granule (GO:0070820) | 3.58E-04 | CEACAM1/TNFAIP6/PLAU/TCN1/SLC11A1/MMP9/CD177 | |
| Secretory granule membrane (GO:0030667) | 3.71E-04 | CEACAM1/PLAU/CEACAM6/ANPEP/SLC11A1/P2RX1/CA4/CD14/CD177 | |
| Tertiary granule membrane (GO:0070821) | 0.0027972 | CEACAM1/PLAU/SLC11A1/CD177 | |
| Microtubule (GO:0005874) | 0.0034919 | TPX2/KIF18B/KIFC1/PLK1/CDK1/KIF20A | |
| Phagocytic vesicle membrane (GO:0030670) | 0.0055745 | ANXA3/SLC11A1/TAP1 | |
| Anchored component of plasma membrane (GO:0046658) | 0.0059288 | CA4/CD14/CD177 | |
| GO Molecular Function | RAGE receptor binding (GO:0050786) | 4.07E-05 | S100A12/S100A9/S100A8 |
| Serine-type peptidase activity (GO:0008236) | 6.65E-05 | PLAU/HTRA3/GZMA/PCSK9/CTSG/MMP9/ELANE | |
| Carbonate dehydratase activity (GO:0004089) | 7.91E-05 | CA12/CA1/CA4 | |
| Serine-type endopeptidase activity (GO:0004252) | 2.00E-04 | PLAU/GZMA/PCSK9/CTSG/MMP9/ELANE | |
| Icosatetraenoic acid binding (GO:0050543) | 9.34E-04 | S100A9/S100A8 | |
| Arachidonic acid binding (GO:0050544) | 9.34E-04 | S100A9/S100A8 | |
| Cobalamin binding (GO:0031419) | 9.34E-04 | TCN2/TCN1 | |
| Endopeptidase activity (GO:0004175) | 0.0010049 | ADAMTS2/ADAM28/PLAU/HTRA3/GZMA/PCSK9/CTSG/MMP9/ELANE | |
| Icosanoid binding (GO:0050542) | 0.0013009 | S100A9/S100A8 | |
| ATP binding (GO:0005524) | 0.0018243 | ACVRL1/ABCB1/KIFC1/OAS3/PLK1/HSPA6/TAP1/TRIP13 |