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. 2023 Jul 17;133(14):e170498. doi: 10.1172/JCI170498

Figure 2. Mesenchymal-epithelial interactions in the alveolar and airway niches.

Figure 2

(A) AT2 and their so-far identified subclusters are shown. Among the identified niche cells are LIFs, MANCs, and LGR5+ cells. Cellular markers are also shown. (B) A WNT-FGF feedback loop mediates epithelial-mesenchymal communication during airway regeneration. AEP, alveolar epithelial progenitor; AMP, AXIN2+ myofibrogenic progenitor; ASMC, airway smooth muscle cell; AT2, alveolar epithelial type 2; BM, basement membrane; Epi, epithelium; IAAP, injury-activated alveolar progenitor; LGR5, leucine-rich repeat containing G protein–coupled receptor 5; LIF, lipofibroblast; MANC, mesenchymal alveolar niche cell; Mes, mesenchyme; RSMC, repair-supportive mesenchymal cell.