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. 2023 Jul 17;133(14):e158348. doi: 10.1172/JCI158348

Figure 2. miR-93-5p expression in 2 baboon models of sepsis and in long-term sepsis survivors.

Figure 2

(A) Left panel: Plasma levels of miR-93-5p at different time points in an E. coli (Gram–) baboon sepsis model (n = 6). Purple bar represents the expression of miR-93-5p before death in baboons that died late after inoculation; red bar represents the expression of miR-93-5p before death in baboons that died early after inoculation. Middle panel: miR-93-5p dynamics in E. coli–inoculated baboons that died late (n = 3). Right panel: miR-93-5p dynamics in E. coli–inoculated baboons that died early (n = 3). (B) Left panel: Plasma levels of miR-93-5p at different time points in an S. aureus (Gram+) baboon sepsis model (n = 5). Purple bar represents the expression of miR-93-5p before death in baboons that died late after inoculation; red bar represents the expression of miR-93-5p before death in baboons that died early after inoculation. Middle panel: miR-93-5p dynamics in S. aureus–inoculated baboons that died late (n = 3). Right panel: miR-93-5p dynamics in baboons S. aureus–inoculated baboons that died early (n = 2). Expression of (C) miR-K12-12* and (D) miR-93-5p in whole blood from long-term survivors of sepsis (n = 23) at 3 different time points: day 0 = shortly after sepsis diagnosis, day 1 = 1 day after diagnosis, and day 7 = 7 days after sepsis diagnosis. The relative expression level was normalized to U6. Data are presented as the mean ± SD. ***P < 0.001 and ****P < 0.0001, by Friedman’s test. (E) Correlation between miR-93-5p levels in plasma and SOPED score (n = 59). (F) Correlation between miR-93-5p levels in plasma and the ALC (n = 48). Data were evaluated by Pearson’s correlation test (E and F).