Table 1.
Characteristics between IPA and non-IPA patients with severe fever with thrombocytopenia syndrome.
| Factors | Total (n = 189) | Non-IPA (n = 150) | IPA (n = 39) | P-value |
|---|---|---|---|---|
| Demographics | ||||
| Age, years | 63.16 ± 11.38 | 62.53 ± 12.09 | 65.59 ± 7.78 | 0.057 |
| Male, n (%) | 100 (52.9) | 74 (49.3) | 26 (66.7) | 0.053 |
| Dead, n (%) | 57 (30.2) | 36 (24.0) | 21 (53.8) | 0.000 |
| aCCI | 3.0 (2.0–4.0) | 3.0 (2.0–4.0) | 4.0 (3.0–4.0) | 0.032 |
| Smoking history, n (%) | ||||
| Current smoking | 40 (21.2) | 22 (14.7) | 18 (46.2) | 0.000 |
| Past smoking | 6 (3.2) | 4 (2.7) | 2 (5.1) | |
| Never smoking | 143 (75.7) | 124 (82.7) | 19 (48.7) | |
| Alcohol consumption, n (%) | 38 (20.1) | 22 (14.7) | 16 (41.0) | 0.000 |
| Clinical manifestation | ||||
| Cough, n (%) | 72 (38.1) | 49 (32.7) | 23 (59.0) | 0.003 |
| Dyspnea, n (%) | 44 (23.3) | 29 (19.3) | 15 (38.5) | 0.012 |
| Laboratory parameters | ||||
| RNA load (lg copies/mL) | 6.32 (5.96–6.61) | 6.32 (5.95–6.38) | 6.48 (6.07–7.16) | 0.019 |
| WBC count (× 109/L) | 3.14 (1.58–6.02) | 2.94 (1.59–5.74) | 4.31 (1.55–7.16) | 0.217 |
| Neutrophil count (× 109/L) | 2.01 (0.96–4.31) | 1.86 (0.94–4.23) | 2.80 (1.11–4.97) | 0.286 |
| Lymphocyte count (× 109/L) | 0.66 (0.42–1.24) | 0.65 (0.41–1.19) | 0.8 (0.45–1.40) | 0.386 |
| Monocyte count (× 109/L) | 0.14 (0.08–0.35) | 0.15 (0.08–0.34) | 0.12 (0.07–0.42) | 0.894 |
| Hemoglobin (g/L) | 131.82 ± 22.22 | 130.35 ± 22.14 | 137.46 ± 21.90 | 0.077 |
| Platelet count (× 109/L) | 39.00 (28.00–55.00) | 39.00 (27.00–55.25) | 39.00 (29.00–53.00) | 0.589 |
| CD3+CD4+ cells (/μL) | 191.50 (123.00–312.50) | 198.00 (121.50–343.75) | 183.50 (122.25–232.00) | 0.285 |
| CD3+CD8+ cells (/μL) | 206.00 (116.25–447.25) | 213.00 (112.75–519.00) | 179.50 (111.00–342.50) | 0.539 |
| CD3−CD19+ (/μL) | 155.50 (61.00–279.50) | 148.50 (58.00–292.00) | 175.00 (119.25–269.00) | 0.601 |
| CD3−CD56+ (/μL) | 124.50 (75.25–206.00) | 124.50 (79.50–206.00) | 115.00 (69.25–268.00) | 0.844 |
| CD3+CD56+ (/μL) | 13.95 (12.14–33.21) | 13.95 (13.19–26.47) | 17.08 (7.63–49.26) | 0.873 |
| CD3+CD69+ (/μL) | 45.83 (28.51–80.02) | 41.15 (25.12–145.75) | 49.56 (29.56–62.00) | 0.690 |
| CD3+CD25+ (/μL) | 58.37 (27.40–106.64) | 60.64 (27.51–131.08) | 50.30 (26.68–74.69) | 0.328 |
| CD3+HLADR+ (/μL) | 158.28 (86.38–299.52) | 156.58 (84.69–313.78) | 159.97 (88.22–294.77) | 0.847 |
| FERR (ng/mL) | 8,577.15 (1,536.93–15,000.00) | 6,962.55 (1,500.00–15,000.00) | 15,000.00 (6,665.37–18,187.50) | 0.001 |
| PCT (ng/mL) | 0.27 (0.13–0.55) | 0.23 (0.12–0.54) | 0.35 (0.21–0.76) | 0.022 |
| IL-6 (ng/mL) | 0.05 (0.02–0.12) | 0.02 (0.01–0.09) | 0.10 (0.05–0.18) | 0.001 |
| PT (s) | 12.20 (11.50–13.00) | 12.20 (11.50–13.00) | 12.10 (11.60–12.90) | 0.996 |
| APTT (s) | 45.30 (38.90–56.33) | 44.20 (38.35–53.55) | 49.00 (42.40–63.30) | 0.026 |
| D-Dimer (mg/L) | 2.59 (1.31–7.79) | 2.54 (1.24–6.58) | 2.70 (1.65–9.39) | 0.593 |
| ALT (U/L) | 111.05 (60.70–168.78) | 102.90 (61.25–162.10) | 129.90 (60.60–172.20) | 0.469 |
| AST (U/L) | 318.60 (165.75–544.68) | 298.20 (152.45–506.15) | 365.10 (232.00–650.70) | 0.059 |
| ALP (U/L) | 74.00 (55.85–114.98) | 71.00 (54.00–112.00) | 87.00 (60.50–132.95) | 0.159 |
| GGT (U/L) | 68.30 (28.50–144.30) | 65.85 (27.35–135.00) | 81.00 (42.85–225.10) | 0.100 |
| LDH (U/L) | 1,107.00 (675.50–1,749.00) | 989.00 (599.00–1,544.00) | 1,489.00 (1,040.00–2,643.50) | 0.001 |
| ADA (U/L) | 41.40 (27.78–63.53) | 39.80 (27.83–62.98) | 47.55 (27.30–69.58) | 0.307 |
| Albumin (g/L) | 30.35 ± 4.81 | 30.49 ± 4.88 | 29.83 ± 4.58 | 0.446 |
| BUN (mmol/L) | 5.91 (4.33–8.15) | 5.42 (4.05–7.62) | 7.70 (5.48–11.69) | 0.000 |
| Creatinine (μmol/L) | 68.00 (56.83–89.88) | 65.90 (53.90–87.40) | 88.10 (66.60–125.10) | 0.000 |
| Pro-BNP (pg/mL) | 973.10 (386.60–4,024.00) | 924.70 (300.90–4,091.50) | 1,121.00 (703.45–4,221.65) | 0.090 |
| FT3 (pmol/L) | 2.22 ± 0.86 | 2.28 ± 0.91 | 1.90 ± 0.46 | 0.064 |
| FT4 (pmol/L) | 12.34 (10.89–15.53) | 12.85 (11.03–15.95) | 10.81 (8.85–13.64) | 0.043 |
| TSH (mIU/L) | 0.72 (0.29–2.21) | 1.10 (0.38–2.38) | 0.35 (0.11–0.68) | 0.019 |
| Additional factors | ||||
| MODS, n (%) | 62 (32.8) | 35 (23.3) | 27 (69.2) | 0.000 |
| ICU admission, n (%) | 58 (30.7) | 29 (19.3) | 29 (74.4) | 0.000 |
| Machined ventilation, n (%) | 30 (15.9) | 15 (10.0) | 15 (38.5) | 0.000 |
| Treatment | ||||
| Broad-spectrum antibiotic therapy, n (%) | 50 (26.5) | 24 (16.0) | 26 (66.7) | 0.000 |
| Corticosteroid use, n (%) | 98 (51.9) | 68 (45.3) | 30 (76.9) | 0.000 |
| < 1 mg/kg | 67 (35.4) | 54 (36.0) | 13 (33.3) | 0.000 |
| ≥1 mg/kg | 31 (16.4) | 14 (9.3) | 17 (43.6) | |
| ≤ 5 d | 59 (31.2) | 42 (28.0) | 17 (43.6) | 0.002 |
| >5 d | 39 (20.6) | 26 (17.3) | 13 (33.3) | |
| Never | 91 (48.1) | 82 (54.7) | 9 (23.1) | |