Table 11. The mean and median cfDNA dosage values and the number of collected samples were subdivided by tumor origin (intestinal, pulmonary, and other sites) and recorded for the various monitoring times (T0–T10).
| T0 | T1 | T2 | T3 | T4 | T5 | T6 | T7 | T8 | T9 | T10 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cfDNA mean a (ng/mL) | Lung | 976.8 | 157.0 | 193.3 | 275.0 | 248.6 | 186.0 | 170.0 | / | / | / | / |
| Intestine | 306.5 | 299.0 | 693.4 | 537.2 | 1,562.6 | 293.2 | 193.7 | 300.0 | 506.0 | 1,115.5 | 250.0 | |
| Others | 550.6 | 96.6 | 286.0 | 228 | 218 | 211 | / | 416 | / | / | / | |
| Samples ( n ) | Lung | 17 | 5 | 8 | 3 | 5 | 3 | 2 | 3 | 0 | 0 | 0 |
| Intestine | 14 | 7 | 5 | 6 | 5 | 4 | 4 | 3 | 3 | 3 | 3 | |
| Others | 8 | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | |
| cfDNA median a (ng/mL) | Lung | 167.0 | 170.0 | 194.0 | 275 | 265.0 | 186.0 | 170.0 | / | / | / | / |
| Intestine | 182.0 | 237.0 | 294.0 | 245.5 | 213.0 | 284.0 | 212.0 | 300.0 | 506.0 | 1,115.5 | 289.0 | |
| Others | 263.5 | 109.0 | 286.0 | 228.0 | 218.0 | 211.0 | / | 416.0 | / | / | / |
Abbreviations: cfDNS, circulating free DNA.
a
The variability, in terms of the inaccuracy of the measurement for cfDNA mean and median values, is 5% (95% confidence interval).