Table 2.

The mutated or acquired AMR genes present in >5% of 783 resistant E. coli strains from 46 studies of relative fitness.

Gene	No. of strains (%), n=7831	Genetic support	AMR family	References
aadA5	49 (6.3%)	Acquisition	Aminoglycosides	McArthur et al. (2013), Poirel et al. (2018), and Rajer and Sandegren (2022)
acrR	58 (7.4%)	Mutation	Multidrug	Praski Alzrigat et al. (2021)
aph(3″)-Ib	50 (6.4%)	Acquisition	Aminoglycosides	McArthur et al. (2013), Poirel et al. (2018), and Tang et al. (2022)
aph(6)-Id	58 (7.4%)	Acquisition	Aminoglycosides	McArthur et al. (2013), Poirel et al. (2018), and Rajer and Sandegren (2022)
blaCTXM-15	52 (6.6%)	Acquisition	Beta-lactams	Poirel et al. (2018) and Alonso-del Valle et al. (2021)
blaOXA	92 (11.7%)	Acquisition	Beta-lactams	Silva et al. (2011) and Poirel et al. (2018)
blaOXA-1	45 (5.7%)	Acquisition	Beta-lactams	Poirel et al. (2018), Palkovicova et al. (2022), and Rajer and Sandegren (2022)
blaTEM	96 (12.3%)	Acquisition	Beta-lactams	Poirel et al. (2018) and Cai et al. (2021)
blaTEM-1	62 (7.9%)	Acquisition	Beta-lactams	Dahlberg and Chao (2003) and Poirel et al. (2018)
blaTEM-1B	46 (5.9%)	Acquisition	Beta-lactams	Poirel et al. (2018), Alonso-del Valle et al. (2021), Rajer and Sandegren (2022), and Tang et al. (2022)
dfrA17	49 (6.3%)	Acquisition	Diaminopyrimidines	Poirel et al. (2018), Brandis et al. (2021), and Tang et al. (2022)
gyrA	191 (24.4%)	Mutation	Fluoroquinolones	Marcusson et al. (2009), Huseby et al. (2017), Wang et al. (2017), and Poirel et al. (2018)
gyrB	62 (7.9%)	Mutation	Fluoroquinolones	Wang et al. (2017) and Poirel et al. (2018)
marR	108 (13.8%)	Mutation	Fluoroquinolones, beta-lactams	Marcusson et al. (2009), Huseby et al. (2017), Wang et al. (2017), Brandis et al. (2021), and Praski Alzrigat et al. (2021)
mph(A)	62 (7.9%)	Acquisition	Macrolides	Liu et al. (2021) and Rajer and Sandegren (2022)
parC	58 (7.4%)	Mutation	Fluoroquinolones	Marcusson et al. (2009) and Poirel et al. (2018)
rpoB	209 (26.7%)	Mutation	Fluoroquinolones, beta-lactams, ansamycins	Angst and Hall (2013), Durão et al. (2015), and Brandis et al. (2021)
rpsL	118 (15.1%)	Mutation	Aminoglycosides	Angst and Hall (2013) and Durão et al. (2015)
sul1	84 (10.7%)	Acquisition	Sulfonamides	Enne et al. (2005) and Poirel et al. (2018)
sul2	68 (8.7%)	Acquisition	Sulfonamides	Enne (2004) and Poirel et al. (2018)
tet(A)	75 (9.6%)	Acquisition	Tetracyclines	Poirel et al. (2018), Alonso-del Valle et al. (2021), and Zhang et al. (2022)
tet(X)	79 (10.1%)	Acquisition	Tetracyclines	Poirel et al. (2018), Rajer and Sandegren (2022), and Tang et al. (2022)

¹Total % higher than 100 because strains can contain multiple AMR genes.