Table 2.
Neonatal outcomes according to lithium exposure
| Total (n = 117) | Non-lithium exposed group (n = 75) | Lithium-exposed group (n = 42) | P-value | |
|---|---|---|---|---|
| Neonatal outcomes | ||||
| Sex, female, n (%) | 62 (53.0) | 44 (58.7) | 18 (42.0) | 0147 |
| Gestational age, mean (SD) | 276.23 (11.10) | 276.55 (11.27) | 275.67 (10.92) | 0.283 |
| Gestational age, weeks + days (SD) | 39 + 4 (1 + 5) | 39 + 5 (1 + 6) | 39 + 4 (1 + 5) | 0.283 |
| Preterm birth, n (%) | 7 (6.0) | 4 (5.3) | 3 (7.1) | NA |
| Birth weight in grams, mean (SD) | 3445.16 (492.94) | 3375.36 (481.14) | 3569.81 (494.80) | 0.040* |
| Percentile weight, mean (SD) | 51.25 (28.58) | 46.72 (27.55) | 59.33 (28.92) | 0.021* |
| Large for gestational age, n (%) | 12 (10.3) | 6 (8.0) | 6 (14.3) | 0.449 |
| Small for gestational age, n (%) | 6 (5.1) | 6 (8.0) | 0 (0.0) | NA |
| Apgar scores | ||||
| Apgar score 1 min, mean (SD) | 7.75 (2.21) | 7.71 (2.32) | 7.83 (2.01) | 7.758 |
| Apgar score 5 min, mean (SD) | 9.50 (1.13) | 9.51 (1.26) | 9.50 (0.89) | 0.973 |
| Neonatal asphyxia**, n (%) | 4 (3.4) | 2 (2.7) | 2 (4.8) | NA |
| Admission to neonatal ward with monitoring, n (%) | 22 (18.8) | 15 (20.0) | 7 (16.7) | 0.844 |
| Duration admission to care unit in days, median (IQR) | 3 (5.00) | 5 (5.00) | 2 (0.75) | NA |
| Congenital malformations, n (%) | 8 (6.9) | 4 (5.3) | 4 (9.5) | NA |
| Readmission ≤ 28 days postpartum | 6 (5.1) | 4 (5.3) | 2 (4.8) | NA |
n number, SD standard deviation, IQR interquartile range, NA not applicable
Chi2 tests were not applicable if value in cell < 5
*p < 0.05.
** According to local protocol