Fig. 3.

Schematic of the Hippo signaling pathway in the regulation of chromatin remodeler complexes. Several upstream stimuli/signals can activate Hippo signaling through the phosphorylation of MST1/MST2 and subsequent phosphorylation of LATS1/LATS2 kinases leading to YAP/TAZ phosphorylation resulting in proteasomal degradation or cytoplasmic retention of YAP/TAZ via 14–3-3 protein. Additionally, Neurofibromatosis 2 (NF2) along with MAP4k and TAOK can also activate Hippo signaling without MST1/MST2 phosphorylation. However, when the Hippo pathway is off, YAP/TAZ will not be phosphorylated, thus, nonphosphorylated YAP/TAZ translocates into the nucleus and form complexes with transcription factors, co-activators as well as different chromatic remodeler complexes to facilitate the transcription target genes. Dotted lines indicate upstream signals