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. 2023 May 6;42(2):409–425. doi: 10.1007/s10555-023-10104-3

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Notch signaling pathway in chromatin regulation. The binding of the notch-ligand from the signaling cells to the notch-receptor of signal-receiving cells promotes the proteolytic cleavages of the notch-receptor. Metalloprotease ADAM10 catalyzes the S2 cleavage followed by γ-secretase dependent catalysis of S3 cleavage, resulting in release of the Notch intracellular domain (NICD). Released NICD translocates into the nucleus, where it interacts with the co-activators and DNA-binding proteins and chromatin modifying complexes for regulating transcription