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. 2023 May 6;42(2):409–425. doi: 10.1007/s10555-023-10104-3

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Fig. 6 — PI3K/AKT signaling dependent epigenetic regulation. In response to extracellular stimuli, membrane-bound receptor RTKs/GPCRs gets activated leading to phosphorylation of PI3K which catalyzes the phosphorylation of PIP2 to produce PIP3 resulting in the activation of Akt. Activated AKT phosphorylates a variety of substrates, including chromatin remodeler complexes, to regulate epigenetic gene regulation