Fig. 3.

Outcome in patients receiving ventilation or HFNO, in risk of death groups based on the PaO₂/FiO₂ cutoffs as in the Berlin definition of ARDS, and in patients receiving HFNO, in risk of death groups based on the tertile PaO₂/FiO₂ cutoffs. ICU mortality is shown in (A). PaO₂/FiO₂ cutoffs as in the Berlin definition were 200–300 (mild ARDS), 100–200 (moderate ARDS) and < 100 mmHg (severe ARDS). PaO₂/FiO₂ cutoffs based on tertiles were 110–300 (mild hypoxemia), 80–110 (moderate hypoxemia) and < 80 mmHg (severe hypoxemia). B shows ICU survival for patients receiving ventilation according to the risk of death groups based on the PaO₂/FiO₂ cutoffs as in the Berlin definition of ARDS. C shows ICU survival for patients receiving HFNO according to the risk of death groups based on the PaO₂/FiO₂ cutoffs as in the Berlin definition of ARDS. D shows ICU survival for patients receiving HFNO using PaO₂/FiO₂ cutoffs based on tertiles. Unadjusted hazard ratios with center as random effect are shown. CI confidence interval, FiO₂ fraction of inspired oxygen, HFNO high-flow nasal oxygen, HR hazard ratio, PaO₂ partial pressure of oxygen