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. 2023 Jul 14;14:4221. doi: 10.1038/s41467-023-40022-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Oncoplot showing IACS response, the origin of PDX (bone metastasis, liver metastasis or breast primary tumour), the ER IHC status and the genomic alterations present in each PDX. B Top enriched hallmarks identified in the GSEA analysis of IACS responder and IACS resistant untreated ER + PDX models. Normalised enrichment scores (NES). C Enrichment plots of G2M checkpoint, interferon alpha response, OXPHOS and PI3K/AKT/mTOR hallmarks significantly associated with IACS response or resistance. NES normalised enrichment score, FDR false discovery rate adjusted p value.