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. 2023 Jul 14;14:4221. doi: 10.1038/s41467-023-40022-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Min/Max whisker plots showing the levels of TCA cycle metabolites in HBCx-124 (n = 5 mice/group) and HBCx-137 PDX (n = 6 mice/group) control and IACS-treated xenografts. (Mean ± SD). P and q values are shown in Supplementary Data 2. Level of aspartate (B) and lactate (C) in HBCx-124 (n = 5 mice/group) and HBCx-137 PDX (n = 6 mice/group) control and IACS-treated xenografts. (Mean ± SD). Min/Max whisker plots. (Two-way ANOVA, FDR corrected). D Metabolites levels of the pentose phosphate pathway metabolism (P and q values are shown in Supplementary Data 2.) in HBCx-124 (n = 5 mice/group) and HBCx-137 PDX (n = 6 mice/group) control and IACS-treated xenografts. (Mean ± SD). Min/Max whisker plots. E Glycogen metabolism in HBCx-124 (n = 5 mice/group) and HBCx-137 PDX (n = 6 mice/group) control and IACS-treated xenografts. (Mean ± SD). Min/Max whisker plots. (Two-way ANOVA, FDR corrected). F Overview of metabolic differences between HBCx-124 and HBCx-137 PDX and of metabolic changes in IACS-treated tumours. Source data are provided as a Source Data file. n number of mice.