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. 2023 Jul 14;13:11424. doi: 10.1038/s41598-023-38609-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased intrinsic and extrinsic apoptosis signaling in OVE spheroids with Trp53 mutation. (A) Representative immunoblots and (B) densitometric analysis for Puma, Bax, and Bcl-xl in OVE spheroids. Vinculin was used as a loading control. (C) Representative immunoblots and (D) densitometric analysis for Trail and Trailr2 in OVE spheroids. Vinculin was used as a loading control. All statistical analyses were performed using one-way ANOVA followed by Tukey’s multiple comparisons test (*p < 0.05; **p < 0.01; ***p < 0.001; n = 3). Error bars represent standard error of the mean. Original blots are presented in Supplemental Fig. S5.