Table 2.
A. Univariate and multivariate Cox regression analysis for PFS in cohort B. B. Univariate and multivariate Cox regression analysis for OS in cohort B.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Characteristic | HR (95% CI) | p-Value | HR (95% CI) | p-Value |
| A | ||||
| Age | 0.99 (0.97–1.01) | 0.18 | ||
| WHO PS (ref 0) | ||||
| 1 | 1.26 (0.78–2.05) | 0.35 | ||
| 2 | 0.75 (0.28–1.97) | 0.56 | ||
| Disease free interval | 1.00 (1.00–1.00) | 0.68 | ||
| Visceral disease (Y/N) | 1.49 (0.96–2.32) | 0.07 | 1.75 (1.12–2.75) | 0.02 |
| CDK4/6i (Y/N) | 0.71 (0.42–1.21) | 0.21 | ||
| CA15.3 ≥ 30 (Y/N) | 1.01 (0.53–1.91) | 0.98 | ||
| Aneuploidy score ≥ 5 (Y/N) | 2.45 (1.57–3.82) | <0.001 | 2.52 (1.56–4.07) | <0.001 |
| CTC-count ≥ 5 (Y/N) | 1.69 (1.08–2.63) | 0.02 | 1.33 (0.83–2.11) | 0.24 |
| B | ||||
| Age | 1.02 (0.98–1.05) | 0.09 | 1.02 (0.99–1.05) | 0.15 |
| WHO PS (ref 0) | ||||
| 1 | 1.95 (1.02–3.74) | 0.04 | 1.54 (0.78–3.04) | 0.22 |
| 2 | 3.95 (1.53–10.15) | 0.004 | 3.43 (1.17–10.0) | 0.03 |
| Disease free interval | 1.00 (1.00–1.00) | 0.46 | ||
| Visceral disease (Y/N) | 2.08 (1.23–3.53) | 0.007 | 2.74 (1.56–4.79) | <0.001 |
| CDK4/6i (Y/N) | 0.96 (0.52–1.75) | 0.88 | ||
| CA15.3 ≥ 30 (Y/N) | 0.92 (0.40–2.12) | 0.85 | ||
| Aneuploidy score ≥ 5 (Y/N) | 2.03 (1.21–3.40) | 0.007 | 2.37 (1.36–4.14) | 0.002 |
| CTC count ≥ 5 (Y/N) | 1.41 (0.84–2.36) | 0.20 | ||
P-values indicate a significant difference in hazard ratio compared to the reference cohort.