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. 2023 Jul 14;14:4196. doi: 10.1038/s41467-023-39653-5

Fig. 5. Hygromycin A potentiates bactericidal properties of macrolide antibiotics.

Fig. 5

Time-kill assays using drug-susceptible Cp2000 strain of S. pneumoniae exposed during various times to antibiotic concentrations at 4x MIC of hygromycin A (HygA, blue plot, 20 µg/ml), macrolides erythromycin (a, ERY, green plot, 0.25 µg/ml), azithromycin (b, AZI, light blue plot, 0.5 µg/ml), or ketolide solithromycin (c, SOL, teal plot, 0.04 µg/ml) alone and in combination with HygA (red, magenta, and orange plots, respectively). The initial number of viable cells (colony-forming units, CFUs) before the addition of drug(s) was arbitrarily assigned to 100%. Error bars show mean standard deviation of 2–4 independent measurements. Source data are provided as a Source Data file.