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. 2023 Jul 14;14:4196. doi: 10.1038/s41467-023-39653-5

Fig. 6. Hygromycin A restores the bactericidal activity of ketolides against Erm-expressing bacteria.

Fig. 6

Time-kill assays using erm-positive macrolide-resistant Cp1290 strain of S. pneumoniae exposed during various times to antibiotic concentrations at 4x MIC of hygromycin A (HygA, blue plot, 20 µg/ml), ketolides telithromycin (a, TEL, magenta plot, 2 µg/ml) or solithromycin (b, SOL, teal plot, 4 µg/ml) alone and in combination with HygA (red and orange plots, respectively). The initial number of viable cells (colony-forming units, CFUs) before the addition of drug(s) was arbitrarily assigned to 100%. Error bars show mean standard deviation of 2–5 independent measurements. Source data are provided as a Source Data file.

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