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. 2023 Jul 14;14:4217. doi: 10.1038/s41467-023-39856-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Scheme of target identification protocol for PPIs. b Chemical structures of four PPIs, rabeprazole, lansoprazole, omeprazole and pantoprazole. c Effect of rabeprazole (12.5 or 50 μM) on the thermal stability of ARF1^WT (2.5 μM) in the PTS assay. d Drug resistance mutation analysis interprets the prediction of omeprazole, and there is a cysteine (C159, the only cysteine residue of ARF1) residue among the important residues. e Effects of rabeprazole on the thermal stability of ARF1^WT (containing DTT) and ARF1^C159A in the PTS assay. f The protein molecular weights of ARF1^WT and ARF1^C159A in the presence or absence of rabeprazole were determined by mass spectrometer. g Summary of PTS assay results. h Potential docking pose of rabeprazole and ARF1 (PDB: 1HUR). i GDP/MANT-GTP nucleotide exchange of ARF1 treated with rabeprazole. Source data are provided as a Source Data file.