Skip to main content
. 2023 Jul 14;9:247. doi: 10.1038/s41420-023-01506-x

Fig. 1. Proinflammatory cytokines induced FKBP5 expression in human islets, mice islets, and clonal β cells.

Fig. 1

A mRNA expression of FKBP5 in human islets from 5 organ donors treated with proinflammatory cytokines (IL-1β 10 ng/mL, TNF-α 25 ng/mL, IFN-γ 100 ng/mL). Experiments were repeated for 3 times. B, C mRNA expression of Fkbp5 in NIT-1 cells (B) and βTC-6 cells (C). Experiments were repeated for 3 times. D, E Western blot of Fkbp5 in NIT-1 cells treated with proinflammatory cytokines (D) and Fkbp5 expression levels were quantified by Image J, with β-actin as loading control. E Experiments were repeated for 3 times. Student’s t-test. Mean ± SEM, *P<0.05, **P<0.01, ***P <0.001.