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. 2023 Jul 14;9:244. doi: 10.1038/s41420-023-01548-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The expression of Hnrnpa1 during the indicated days of cardiomyocyte differentiation. B Co-IP analysis for the interaction of ZHX1 and hnRNPA1. C The average profiles of ZHX1 and hnRNPA1 ChIP-seq at the genome-wide level in 46C-Ctrl cells and the hnRNPA1 ChIP-seq at the genome-wide level in Zhx1-KO cells. D Genome-wide heatmaps of the ZHX1 and hnRNPA1 enrichment of target genes in 46C-Ctrl cells, and the hnRNPA1 enrichment of target genes in Zhx1-KO cells. E Venn diagram shows the number of ZHX1/hnRNPA1 co-target genes in the CP stage. F RNA-seq scatterplot shows the upregulated (1788, green) and downregulated (1472, red) genes after Zhx1 knockout. G Cross-analysis for the co-target genes of ZHX1/hnRNPA1 and downregulated genes after Zhx1 knockout. H GO analysis for the co-target genes of ZHX1/hnRNPA1 which were downregulated after Zhx1 knockout. I Genome browser screenshots of ZHX1 and hnRNPA1 ChIP-seq on Mef2c, Src, and Epas1 genes in 46C-Ctrl cells, and hnRNPA1 ChIP-seq on Mef2c, Src, and Epas1 genes in Zhx1-KO cells. J ChIP analysis for the ZHX1 binding at the promoters of Mef2c, Src, and Epas1 genes. K ChIP analysis for the hnRNPA1 binding at the promoters of Mef2c, Src, and Epas1 genes after Zhx1 knockout. Data are presented as the mean ± SEM (n = 3). The statistical significance is performed according to Student’s t-tests (unpaired two-tailed). *p < 0.05, **p < 0.01, and ***p < 0.001 versus IgG or 46C-Ctrl.