Table 2.

Correlation of fatigue levels (No fatigue/low to moderate fatigue/high fatigue) to clinical and volumetric data.

		Fatigue severity
Age	Spearman coefficient	0.256*
	Sig. (2-tailed)	0.034
Sex	Spearman coefficient	0.095
	Sig. (2-tailed)	0.192
Disease duration	Spearman coefficient	0.402**
	Sig. (2-tailed)	0.002
Number of relapses	Spearman coefficient	0.333**
	Sig. (2-tailed)	0.009
EDSS	Spearman coefficient	0.430**
	Sig. (2-tailed)	0.001
Time to initiate DMT	Spearman coefficient	0.271*
	Sig. (2-tailed)	0.028
Whole brain volume	Spearman coefficient	− 0.423-**
	Sig. (2-tailed)	0.002
Lesion count	Spearman coefficient	0.361**
	Sig. (2-tailed)	0.005
Lesion volume	Spearman coefficient	0.418**
	Sig. (2-tailed)	0.002
Juxtacortical lesion count	Spearman coefficient	0.351**
	Sig. (2-tailed)	0.006
Juxtacortical lesion volume	Spearman coefficient	0.287*
	Sig. (2-tailed)	0.023
Periventricular lesion count	Spearman coefficient	0.171
	Sig. (2-tailed)	0.106
Periventricular lesion volume	Spearman coefficient	0.382**
	Sig. (2-tailed)	0.003
Infratentorial lesion count	Spearman coefficient	0.411**
	Sig. (2-tailed)	0.002
Infratentorial lesion volume	Spearman coefficient	0.375**
	Sig. (2-tailed)	0.003