Table 1.

Minor allele frequencies (MAF) of variants identified within the P. falciparum parasites on Ngodhe island and their respective frequencies across East African and West African parasite populations (minimum read depth > tenfold).

Gene	SNP	Ngodhe island			Mfangano island			East Africa1	West Africa2
		MAF	95% CI	n	MAF	95% CI	n	MAF (n = 228)	MAF (n = 167)
Pfcrt	M74I	6.5	2.2–18	46	0	0–12	27	0	0
	N75E	4.4	1.5–15	45	0	0–12	27	0	0
	K76T	4.4	1.5–15	45	7.4	2.1–23	27	17.5	13.0
	H97Y	0	0–7.9	45	0	0–12	27	0	0
Pfmdr1	F61Y	3.5	0.97–12	57	0	0–11	30	0	0
	N86Y	2.0	0.35–10	50	0	0–11	30	15.7	24.4
	Y184F	47.1	34–60	51	31.7	0–11	30	39.0	15.5
	T199S	13.5	6.7–25	52	3.1	0.55–16	32	0.01	0
	F938Y	3.0	0.83–10	66	0	0–11	31	8.3	22.2
	F1072Y	2.0	0.37–11	48	0	0–10	35	0	0
	D1246Y	16.0	7.1–33	31	2.9	0.51–15	35	12.9	31.2
Pfk13	A578S	3.1	0.83–11	65	0	0–10	35	1.1	0
	F451Y	4.5	1.6–13	66	0	0–10	35	0	0
Pfdhfr	N51I	77.0	62–85	53	100	90–100	34	91.4	92.5
	C59R	76.9	64–86	52	91.2	77–97	34	86.4	93.0
	S108N	80.8	68–89	52	100	90–100	36	99.4	93.0
	I164L	5.8	2.0–16	52	6.9	2.9–22	36	1.5	0
Pfdhps	S436H	11.9	5.2–25	42	22.9	12–39	35	0	0
	G437A	100	92–100	42	100.0	90–100	35	85.3	70.0
	K540E	79.2	66–88	48	95.7	85–99	35	84.4	30.0

¹East Africa: Kenya, Tanzania, and Uganda.

²West Africa: The Gambia and Mauritania.

bold - mutations with known resistance associations.