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. 2023 Jul 14;14(7):431. doi: 10.1038/s41419-023-05951-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Tumor growth was not affected in mice subcutaneously transplanted with GSV-Ywhaz subclones with Dox treatment (n = 6; ns, not significant). B The total number of macro-metastatic lung nodules decreased with Dox treatment (+Dox) as compared to the control group (−Dox). Mice were sacrificed on day 60 after subcutaneous transplantation of GSV-Ywhaz (n = 6, *p < 0.05). C Representative images of macro-metastatic lung nodules. D Overall survival time was prolonged when intravenously transplanting GSV-Ywhaz subclone into mice with or without Dox treatment (n = 6, *p < 0.05, Kaplan–Meier survival analysis). E Western blotting analysis showed the upregulation of YWHAZ expression in GSV-Ywhaz subclones and downregulation of YWHAZ expression after DOX treatment.