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. 2023 Jul 14;14(7):431. doi: 10.1038/s41419-023-05951-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The GSV-Ywhaz subclone showed enhanced invasion capacity as compared to the parental Pan02-4B3 cells with transwell assay (n = 3, ***p < 0.0001). B YWHAZ overexpression promotes tumor invasion in Pan02 cells with transwell assay (n = 3, *p < 0.05). C YWHAZ overexpression in AsPC-1 cells resulted in enhanced invasion capacity with transwell assay (n = 3, *p < 0.05). D The GSV-Ywhaz subclone showed enhanced anchorage-independent growth capacity in soft agar as compared to the parental Pan02-4B3 cells (n = 5, ***p < 0.0001). E YWHAZ overexpression promotes anchorage-independent growth in soft agar in Pan02 cells (n = 6, ***p < 0.0001). F YWHAZ overexpression resulted in enhanced anchorage-independent growth capacity in soft agar in AsPC-1 cells. (n = 6, ***p < 0.05). The representative image of colonies was shown. G The expression of differentiation and EMT-related markers were investigated by qPCR (n = 3, *p < 0.05). H The expression of differentiation and EMT-related markers in the GSV–Ywhaz subclone was compared with or without Dox treatment by qPCR. The expression of mRNA was normalized against GAPDH (n = 3, *p < 0.05). I Western Blotting analysis showed the downregulation of E-cadherin expression, the upregulation of phosphorylated AKT (pAKT), and Snail expression in GSV-Ywhaz subclone.