Table 2.
The top 5 candidate genes identified in the highly metastatic subclones.
| Genes | Integration sites | Metastatic sites | Frequency | −Dox (n, %) | Models |
|---|---|---|---|---|---|
| Errfi1 | First intron | Lung, kidney, brain, bone, skin | 26 | 19 (73.1) | i.v. |
| Vmp1 | First intron | Lung, kidney, brain, bone, skin | 26 | 19 (73.1) | i.v. |
| Anxa2 | Third intron | Liver, kidney, adrenal, lung, brain | 21 | 7 (33.3) | o.r. |
| Ywhaz | Second intron | Lung, liver, kidney, brain, bone | 20 | 15 (75) | s.c. |
| Anxa3 | Second intron | Lung, liver | 8 | 5 (62.5) | i.p. |
The candidates were ranked by the frequency in all highly metastatic subclones. “−Dox” indicates the subclones were cultured from the mice without DOX treatment.