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. 2023 Jul 14;13:11418. doi: 10.1038/s41598-023-38638-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Notch2 is expressed in callus tissue. (a) Expression of Notch2 in the fracture callus of WT mice at the indicated time points. Hd = non-fractured, healthy diaphysis (b) Expression of the Notch receptor ligands Jagged1 (Jag1), Jagged2 (Jag2), and Delta-like-canonical-Notch-ligand-1 (Dll1) in the same samples. (c) Representative images of immunofluorescent stainings of Notch2 in the indicated femoral compartments. Upper row: non-fractured and fractured femur of WT mice. Lower row: non-fractured and fractured femur of HCS mice. Scale bar = 100 μm. Dotted white lines show trabecular bone (growth plate), non-fractured cortical bone (diaphysis), or fracture ends (diaphysis), respectively. (d) Quantification of respective immunofluorescent signal intensities of Notch2. For (a, b, d), non-parametric Mann–Whitney U test, *p < 0.05; **p < 0.005. Data are shown as mean with standard deviation. Data points indicate individual measurements from each mouse.