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. 2023 Jul 14;13:11418. doi: 10.1038/s41598-023-38638-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Normal histological callus maturation but increased osteoclast numbers in HCS mice. (a) Representative callus sections (Movat’s Pentachrome staining) of WT and HCS mice at the indicated time points (yellow = mineralized bone; green = cartilage; reddish/brown = bone marrow). Scale bar = 100 μm. Images were captured with CellSens Standard V4.1, Olympus, https://www.olympus-lifescience.com/de/software/cellsens/Tokio, Japan. (b) Histomorphometric quantification of static callus parameters (cartilage and mineralized area) in the same mice. (c) Representative images of tartrate-resistant acid phosphatase stainings 21 days after femoral osteotomy, osteoclasts are stained in red. The corresponding quantitative analysis is displayed on the right. Scale bar = 100 μm. For (a–c), non-parametric Mann–Whitney U test, *p < 0.05. Data are shown as mean with standard deviation. Data points indicate individual measurements from each mouse.