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. 2023 Jul 14;6(7):e2323495. doi: 10.1001/jamanetworkopen.2023.23495

Table 2. Pregnancy Outcomes Among Groupsa .

Outcome, No. (%) Comparison group Reference group P value Unadjusted analysis Adjusted analysis
OR (95% CI) P value OR (95% CI) P value
Groups A (n = 642) vs C (n = 2565 [reference])b
Live birth 323 (50.31) 1212 (47.25) .17 1.13 (0.95-1.34) .17 1.13 (0.95-1.34) .19
Biochemical pregnancy 447 (69.63) 1708 (66.59) .14 1.15 (0.95-1.39) .14 1.14 (0.94-1.38) .17
Clinical pregnancy 395 (61.53) 1483 (57.82) .09 1.17 (0.98-1.39) .09 1.16 (0.97-1.39) .10
Ectopic pregnancy 5 (0.78) 22 (0.86) .75 0.85 (0.32-2.26) .75 0.85 (0.32-2.25) .74
Early miscarriage 59 (9.19) 224 (8.73) .93 0.99 (0.72-1.35) .93 1.00 (0.73-1.36) .10
Late miscarriage 8 (1.25) 27 (1.05) .79 1.12 (0.50-2.47) .79 1.07 (0.48-2.38) .87
Singleton preterm delivery 44 (6.85) 133 (5.19) .12 1.35 (0.92-1.96) .12 1.38 (0.94-2.01) .10
Groups B (n = 151) vs C (n = 600 [reference])c
Live birth 85 (56.29) 321 (53.50) .54 1.12 (0.78-1.60) .54 1.12 (0.78-1.60) .54
Biochemical pregnancy 117 (77.48) 432 (72.00) .17 1.34 (0.88-2.04) .18 1.33 (0.88-2.04) .18
Clinical pregnancy 99 (65.56) 383 (63.83) .69 1.08 (0.74-1.57) .69 1.08 (0.74-1.57) .70
Ectopic pregnancy 1 (0.66) 5 (0.83) .81 0.77 (0.09-6.68) .81 0.73 (0.08-6.33) .77
Early miscarriage 12 (7.95) 47 (7.83) .97 0.99 (0.50-1.94) .97 0.99 (0.50-1.94) .97
Late miscarriage 1 (0.66) 11 (1.83) .29 0.35 (0.04-2.71) .31 0.35 (0.04-2.73) .32
Singleton preterm delivery 11 (7.28) 28 (4.67) .11 1.88 (0.87-4.07) .11 2.04 (0.93-4.49) .08
Groups B (n = 146) vs A (n = 480 [reference])d
Live birth 85 (58.22) 253 (52.71) .24 1.25 (0.86-1.82) .24 1.20 (0.82-1.76) .34
Biochemical pregnancy 114 (78.08) 342 (71.25) .10 1.44 (0.93-2.23) .11 1.35 (0.86-2.12) .19
Clinical pregnancy 97 (66.44) 304 (63.33) .49 1.15 (0.78-1.69) .50 1.06 (0.71-1.58) .78
Ectopic pregnancy 1 (0.68) 5 (1.04) .67 0.62 (0.07-5.40) .67 0.46 (0.05-4.21) .49
Early miscarriage 10 (6.85) 40 (8.33) .46 0.76 (0.36-1.58) .46 0.74 (0.35-1.56) .43
Late miscarriage 1 (0.68) 6 (1.25) .54 0.52 (0.06-4.35) .54 0.48 (0.06-4.14) .50
Singleton preterm delivery 11 (7.53) 34 (7.08) .83 1.09 (0.51-2.34) .83 1.10 (0.51-2.37) .81
a

Group A indicates hepatitis B surface antigen (HBsAg) positive and hepatitis Be antigen (HBeAg) negative; group B, HBsAg positive and HBeAg positive; and group C, HBsAg negative and HBeAg negative.

b

The multiple logistic regression model was adjusted for propensity scores (age of women, body mass index, duration of infertility, type of infertility, basal sex hormone level [estradiol, progesterone, follicle-stimulating hormone (FSH), and luteinizing horomone (LH)], antimüllerian hormone [AMH] level, endometrial preparation protocols, endometrial thickness, the number of good-quality embryos transferred, and the type of embryos transferred) and luteinizing hormone level.

c

The multiple logistic regression model was adjusted for propensity scores (age of women, body mass index, duration of infertility, type of infertility, basal sex hormone level [estradiol, progesterone, FSH, and LH], AMH level, endometrial preparation protocols, endometrial thickness, the number of good-quality embryos transferred, and the type of embryos transferred).

d

The multiple logistic regression model was adjusted for propensity scores (age of women, body mass index, duration of infertility, type of infertility, basal sex hormone level [estradiol, progesterone, FSH, and LH], AMH level, endometrial preparation protocols, endometrial thickness, the number of good-quality embryos transferred, and the type of embryos transferred), age of women, and AMD level.