TABLE 1.
Nuclear receptor reporter cell lines and model agonists/antagonists.
| Reporter cell line | Reporter gene | Nuclear receptor | Reference agonist | Reference antagonist |
|---|---|---|---|---|
| HG5LN | GAL4RE5-βGlobin-Luc-neomycin | |||
| HG5LN PPARγ | GAL4RE5-βGlobin-Luc-neomycin | GAL4-PPARγ-puromycin | Rosiglitazone | T 0070907 |
| HG5LN PXR | GAL4RE5-βGlobin-Luc-neomycin | GAL4-PXR-puromycin | SR12813 | SPA70 |
| HG5LN CAR | GAL4RE5-βGlobin-Luc-neomycin | GAL4-CAR-puromycin | CITCO | PK11195 |
| HELN | ERE-βGlobin-Luc-neomycin | |||
| HELN RARβ (ERα DBD) | ERE-βGlobin-Luc-neomycin | RARβ-puromycin (RXRα endogenous) | CD3254 | UV3003 |