Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 30;14:1192216. doi: 10.3389/fendo.2023.1192216

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Mendoza-León, Mangalam, Regaldiz, González-Madrid, Rangel-Ramírez, Álvarez-Mardonez, Vallejos, Méndez, Bueno, Melo-González, Duarte, Opazo, Kalergis and Riedel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Regulation of thyroid hormone secretion and synthesis by the hypothalamus, pituitary, and thyroid gland axis (HPT axis). The hypothalamus produces and secretes thyrotropin-releasing hormone (TRH), which induces the release thyroid-stimulating hormone (TSH) by the pituitary gland. TSH stimulates the synthesis and production of T₃ and T₄ in the bloodstream. An increase of T₃ and T₄ serum levels activates a negative feedback loop over the hypothalamus and pituitary gland decreasing the production of TRH and TSH, thereby reducing the plasmatic levels of thyroid hormones (THs) (40, 42).