Table 2.

Genes enriched in proliferation- and osteogenic differentiation-related phenotypes

Phenotype	Phenotype-related keywords	GO_ID	GO_term	Type	diff_gene_number	diff_gene_list	rich_factor	P value
Proliferation	Division	GO:0140014	Mitotic nuclear division	Biological_process	11	CDC20, MYBL2, MKI67, PLK1, UBE2C, CHMP1A, CDCA5, DLGAP5, CHMP1B, MIS12, IGF2	5.60	2.71E-06
		GO:0051301	Cell division	Biological_process	15	AL358472.7, KIF20A, SFN, SAPCD2, CDCA5, TXNIP, CDC20, PLK1, UBE2C, CHMP1A, CHMP1B, CABLES1, MIS12, PDGFD, IGF2	3.59	1.86E-05
	Proliferation	GO:0008283	Cell population proliferation	Biological_process	37	EPCAM, NGFR, GLI1, SAPCD2, EFNB1, TXNIP, MAPK14, MKI67, CLDN1, TIMP2, CDC20, SFN, EMC10, PPARGC1A, RERG, CSF3, IGF2, AKIRIN1, WNT5A, RORA, PTPRU, BMP6, BDNF, PDPN, BCL2L2, EDNRB, NR4A1, PTHLH, GPR183, NUDT16, IL23A, PRDM1, EGR1, PDGFD, TGM2, NR4A3, IL11	2.57	4.11E-07
	Mitotic	GO:0000278	Mitotic cell cycle	Biological_process	16	UBE2C, MYBL2, MKI67, CDCA5, CDC20, TIMP2, PLK1, CHMP1A, AL358472.7, KIF20A, SFN, SAPCD2, DLGAP5, IGF2, CHMP1B, MIS12	2.15	3.71E-03
Osteogenic differentiation	Osteoblast	GO:0045667	Regulation of osteoblast differentiation	Biological_process	5	GLI1, ATF4, FBN2, BMP6, RANBP3L	5.41	8.79E-04
		GO:0001649	Osteoblast differentiation	Biological_process	7	ATF4, GLI1, RANBP3L, IGF2, BMP6, FBN2, PTHLH	4.32	6.19E-04
	Bone/mineralization	GO:0030282	Bone mineralization	Biological_process	5	ATF4, ENPP1, PTHLH, FBN2, BMP6	6.38	3.78E-04
	Ossification	GO:0030278	Regulation of ossification	Biological_process	5	MAPK14, WNT5A, BMP6, FBN2, ENPP1	6.33	3.94E-04
		GO:0001503	Ossification	Biological_process	12	ATF4, GLI1, MAPK14, ENPP1, FBN2, BMP8B, PTHLH, BMP6, WNT5A, IGF2, BMP8A, RANBP3L	4.23	2.06E-05