Fig. 4.

Effect of POLA2 on gene mutations in HCC. (A) Top 20 mutated genes in POLA2 high and low expression group. (B) Significant different mutation genes in POLA2 low and high expression groups. (C) Kaplan-Meier curves for HCC patiernts with or without mutations of above significant different mutation genes. (D) The variant allele frequency (VAF) of genes in POLA2 high expression group and POLA2 low expression group. (E) TMB value for HCC patients in POLA 2 high expression group and POLA2 low expression group. (F) Analysis mutation concurrence in the different mutated genes between POLA2 high and low expression groups