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. 2023 Jul 15;21:470. doi: 10.1186/s12967-023-04256-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Deconvolution analyses in melanoma and BRCA cohorts. A Bar plot showing the estimated proportion of the three subcutaneous adipocyte subtypes in each TCGA melanoma sample. B Kaplan–Meier survival curve for TCGA melanoma cohort in five groups. P value was calculated with log‑rank test. Log‑rank p value < 0.05 was considered as statistically significant. C Bar plot showing the estimated proportion of the three subcutaneous adipocyte subtypes in each TCGA breast cancer sample. D Kaplan–Meier survival curve for TCGA breast cancer cohort in five groups. P value was calculated with log‑rank test. Log‑rank p value < 0.05 was considered as statistically significant. E Forest plots for multivariate regression of clinical factors and adipocyte subtypes in TCGA breast cancer datasets. F Pearson’s correlation of GDSC2 drug response (measured by IC50) with each of the four subcutaneous adipocyte subtype scores reveals drug resistance (blue) or sensitivity (red)