Table 2.
Additive interaction of serum vitamin D levels with genetic risk and sleep patterns.
| Insufficient | Deficient | |||
|---|---|---|---|---|
| RERI (95% CI) | AP (95% CI) | RERI (95% CI) | AP (95% CI) | |
| Sleep patterns | ||||
| Intermediate sleep | 0.146 (0.024, 0.267) | 0.113 (0.018, 0.209) | 0.083 (−0.123, 0.289) | 0.061 (−0.088, 0.209) |
| Poor sleep | 0.182 (−0.168, 0.534) | 0.118 (−0.098, 0.333) | 0.061 (−0.429, 0.550) | 0.038 (−0.263, 0.340) |
| Genetic risk | ||||
| Intermediate genetic risk | −0.010 (−0.177, 0.156) | −0.008 (−0.130, 0.115) | 0.154 (−0.112, 0.421) | 0.096 (−0.064, 0.257) |
| High genetic risk | −0.085 (−0.266, 0.097) | −0.050 (−0.158, 0.058) | −0.079 (−0.362, 0.204) | −0.045 (−0.209, 0.119) |
To estimate RERI and AP, references were optimal vitamin D concentrations, low genetic risk, and healthy sleep pattern.
Models for genetic risk and sleep patterns were adjusted for age, sex, race, BMI, income, education, smoking status, assessment center, and vitamin D supplements.
AP, Attributable proportion due to interaction; RERI, relative excess risk due to interaction; CI, Confidence Interval.