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. 2023 Jun 30;11:1208315. doi: 10.3389/fcell.2023.1208315

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Copyright © 2023 Swahn, Olmer and Lotz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TIPARP as a novel candidate therapeutic target in OA cartilage. (A) Venn diagram showing intersection of highly expressed (top 10%) RBPs in healthy cartilage, GTEx cartilage-enriched RBPs and DE RBPs in OA cartilage. (B) Box plot showing TIPARP normalized counts from healthy (n = 18) and OA (n = 20) cartilage samples. ****p < 0.0001 by unpaired Student’s t-test. For all panels, cartilage bulk RNA-seq data from (Fisch et al., 2018). (C, D) IHC (C) and quantification (D) of TIPARP protein in OA compared to healthy in articular cartilage. Error bars are standard deviation, n = 6 (healthy) and n = 6 (OA). *p<0.05 by two-tailed unpaired Student’s t-test.